Amplitude and Phase Synchronization Stability of Auditory Evoked Potentials with Influence of Transcranial Magnetic Stimulation
DOI:
https://doi.org/10.11113/mjfas.v21n5.4154Keywords:
Auditory evoked potentials, electroencephalography, Anacardium occidentale, Transcranial Magnetic StimulationAbstract
The integration of Transcranial Magnetic Stimulation (TMS) with Electroencephalography (EEG) offers a robust framework for investigating brain function and underlying neural mechanisms. While most TMS-EEG studies have focused on TMS-evoked potentials (TEPs) to examine the immediate cortical effects of TMS, limited attention has been given to its influence on the auditory cortex, particularly in terms of how long the modulation persists. This study aims to analyze the effects of TMS on Auditory Evoked Potentials (AEPs), with a focus on changes observed 1 and 2 seconds after stimulation. Single-pulse TMS was applied with a 4-second interstimulus interval (ISI) and presented simultaneously with auditory stimuli delivered at a 1-second ISI. The influence of TMS on AEPs was assessed using time-domain averaging and phase synchronization stability analysis. Results showed minimal differences in the averaged N100 and P200 components between TMS and sham conditions at 2 seconds post-stimulation with ANOVA p=0.08. However, phase stability analysis revealed significantly higher synchronization in the N100 wave 1 second after TMS ANOVA p=0.01, followed by increased stability in the P200 and P300 components compared to the sham condition. These findings highlight the importance of advanced analytical techniques in detecting subtle and transient neural changes induced by TMS. By providing insights into the temporal characteristics of TMS-modulated auditory processing, this study contributes to the development of more targeted diagnostic and therapeutic applications involving non-invasive brain stimulation.
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