Shearlet Transform and Convolutional Neural Network for Histopathology Images in Breast Cancer Classification
DOI:
https://doi.org/10.11113/mjfas.v21n4.3842Keywords:
Shearlet transform, image classification, convolutional neural network, breast cancerAbstract
Breast cancer stands out as one of the global health threats, as it may cause death if improperly treated. Thus, detecting the illness at the early stage through precise diagnosis is important to prevent progression of tumors with effective treatments through medical imaging. Traditionally, manual diagnostic processes rely on the input data representation and expert knowledge, which consume much time and are prone to human error due to heavy workloads and fatigue. Recently, deep learning has shown distinguishing results in medical imaging analysis for image classification and detection. Nevertheless, the increasing demand to enhance the performance of image classification is becoming more prominent. In this study, a hybrid method of deep learning is proposed by combining Shearlet transform and convolutional neural network (CNN) for breast cancer histopathology image classification. First, the histopathology images are decomposed using Shearlet transform for Shearlet coefficients. Then, the CNN approach is used to classify the images into benign and malignant with minimal pre-processing procedure. The ability of Shearlet transform to address singularities helps to increase the quality of images. The proposed hybrid model improves the performance of the original basic CNN model. Results from the experiment show that the proposed hybrid model achieves an accuracy of 75%, an F1-score of 85% for malignant tumor, and a misclassification rate of 0.25%. This result shows that the use of Shearlet transform as the first feature extraction layer in the CNN architecture provides better feature extraction, consequently leading to improved accuracy for image classification.
References
Wilkinson, L., & Gathani, T. (2022). Understanding breast cancer as a global health concern. British Journal of Radiology, 95(1130), 20211033. https://doi.org/10.1259/bjr.20211033
Mubarik, S., et al. (2022). Breast cancer mortality trends and predictions to 2030 and its attributable risk factors in east and south asian countries. Frontier in Nutrition, 9(2022). https://doi.org/10.3389/fnut.2022.847920
Ibrahim, S., Nazir, S., & Velastin, S. A. (2021). Feature selection using correlation analysis and principal component analysis for accurate breast cancer diagnosis. Journal of Imaging, 7(11), 225. https://doi.org/10.3390/jimaging7110225
Smith-Bindman, R., Miglioretti, D. L., & Larson, E. B. (2008). Rising use of diagnostic medical imaging in a large integrated health system. Health Affairs (Millwood), 27(6), 1491–1502. https://doi.org/10.1377/hlthaff.27.6.1491
Vuong, T. T. L., et al. (2022). Multi-scale binary pattern encoding network for cancer classification in pathology images. IEEE Journal of Biomedical and Health Informatics, 26(3), 1152–1163. https://doi.org/10.1109/JBHI.2021.3099817
Gao, Z., et al. (2022). A convolutional neural network and graph convolutional network based framework for classification of breast histopathological images. IEEE Journal of Biomedical and Health Informatics, 26(7), 3163–3173. https://doi.org/10.1109/JBHI.2022.3153671
Yan, R., et al. (2020). Breast cancer histopathological image classification using a hybrid deep neural network. Methods, 173, 52–60. https://doi.org/10.1016/j.ymeth.2019.06.014
Xu, Y., et al. (2017). Large scale tissue histopathology image classification, segmentation, and visualization via deep convolutional activation features. BMC Bioinformatics, 18(1), 281–297. https://doi.org/10.1186/s12859-017-1685-x
Rezaeilouyeh, H., & Mahoor, M. H. (2016). Automatic gleason grading of prostate cancer using shearlet transform and multiple kernel learning. Journal of Imaging, 2(3), 25. https://doi.org/10.3390/jimaging2030025
Kavitha, M., Lavanya, G., Janani, J., & Balaji, J. (2018). Enhanced SVM classifier for breast cancer diagnosis. International Journal of Engineering Technologies and Management Research, 5(3), 67–74. https://doi.org/10.29121/ijetmr.v5.i3.2018.178
Asri, H., et al. (2016). Using machine learning algorithms for breast cancer risk prediction and diagnosis. Procedia Computer Science, 83, 1064–1069. https://doi.org/10.1016/j.procs.2016.04.224
Al-Salihy, N. K., & Ibrikci, T. (2017). Classifying breast cancer by using decision tree algorithms. In Proceedings of the 6th International Conference on Software and Computer Applications (pp. 144–148). ACM Press.
Al-antari, M. A., et al. (2018). A fully integrated computer-aided diagnosis system for digital X-ray mammograms via deep learning detection, segmentation, and classification. International Journal of Medical Informatics, 117, 44–54. https://doi.org/10.1016/j.ijmedinf.2018.06.003
Md Idris, N., et al. (2020). Feature selection and risk prediction for patients with coronary artery disease using data mining. Medical & Biological Engineering & Computing, 58, 3123–3140. https://doi.org/10.1007/s11517-020-02268-9
LeCun, Y., Bengio, Y., & Hinton, G. (2015). Deep learning. Nature, 521, 436–444. https://doi.org/10.1038/nature14539
Sharma, A. K., et al. (2023). Brain tumor classification using the modified ResNet50 model based on transfer learning. Biomedical Signal Processing and Control, 86, 105299–105312. https://doi.org/10.1016/j.bspc.2023.105299
Anisuzzaman, D. M., et al. (2021). A deep learning study on osteosarcoma detection from histological images. Biomedical Signal Processing and Control, 69, 102931–102939. https://doi.org/10.1016/j.bspc.2021.102931
AlZoubi, A., et al. (2024). Classification of breast lesions in ultrasound images using deep convolutional neural networks: Transfer learning versus automatic architecture design. Medical & Biological Engineering & Computing, 62(1), 135–149. https://doi.org/10.1007/s11517-023-02922-y
Khan, S. U., et al. (2019). A novel deep learning based framework for the detection and classification of breast cancer using transfer learning. Pattern Recognition Letters, 125, 1–6. https://doi.org/10.1016/j.patrec.2019.03.022
Alkhathlan, L., & Saudagar, A. K. J. (2022). Predicting and classifying breast cancer using machine learning. Journal of Computational Biology, 29(6), 497–514. https://doi.org/10.1089/cmb.2021.0236
Peng, B., et al. (2018). Fully convolutional neural networks for tissue histopathology image classification and segmentation. In 2018 25th IEEE International Conference on Image Processing (ICIP) (pp. 1403–1407). IEEE.
Priego-Torres, B. M., et al. (2020). Automatic segmentation of whole-slide H&E stained breast histopathology images using a deep convolutional neural network architecture. Expert Systems with Applications, 151, 113387–113400. https://doi.org/10.1016/j.eswa.2020.113387
Murtaza, G., et al. (2020). Ensembled deep convolution neural network-based breast cancer classification with misclassification reduction algorithms. Multimedia Tools and Applications, 79(25), 18447–18479. https://doi.org/10.1007/s11042-020-08692-1
Al-antari, M. A., Han, S. M., & Kim, T. S. (2020). Evaluation of deep learning detection and classification towards computer-aided diagnosis of breast lesions in digital X-ray mammograms. Computer Methods and Programs in Biomedicine, 196, 105584–105598. https://doi.org/10.1016/j.cmpb.2020.105584
Arafa, D. A., et al. (2024). A deep learning framework for early diagnosis of Alzheimer’s disease on MRI images. Multimedia Tools and Applications, 83, 3767–3799. https://doi.org/10.1007/s11042-023-15738-7
Khoramshahi, E., et al. (2020). An image-based real-time georeferencing scheme for a UAV based on a new angular parametrization. Remote Sensing, 12(19), 1–27. https://doi.org/10.3390/rs12193185
Gedik, N. (2016). A new feature extraction method based on multi-resolution representations of mammograms. Applied Soft Computing, 44, 128–133. https://doi.org/10.1016/j.asoc.2016.04.004
Zhou, S., et al. (2013). Shearlet-based texture feature extraction for classification of breast tumor in ultrasound image. Biomedical Signal Processing and Control, 8(6), 688–696. https://doi.org/10.1016/j.bspc.2013.06.011
Talo, M., et al. (2019). Convolutional neural networks for multi-class brain disease detection using MRI images. Computerized Medical Imaging and Graphics, 78, 101673–101684. https://doi.org/10.1016/j.compmedimag.2019.101673
Hashemzehi, R., et al. (2020). Detection of brain tumors from MRI images base on deep learning using hybrid model CNN and NADE. Biocybernetics and Biomedical Engineering, 40(3), 1225–1232. https://doi.org/10.1016/j.bbe.2020.06.001
Farhan, A. M. Q., & Yang, S. (2023). Automatic lung disease classification from the chest X-ray images using hybrid deep learning algorithm. Multimedia Tools and Applications, 82(25), 38561–38587. https://doi.org/10.1007/s11042-023-15047-z
Sudharshan, P. J., et al. (2019). Multiple instance learning for histopathological breast cancer image classification. Expert Systems with Applications, 117, 103–111. https://doi.org/10.1016/j.eswa.2018.09.049
Kumar, A., et al. (2020). Deep feature learning for histopathological image classification of canine mammary tumors and human breast cancer. Information Sciences, 508, 405–421. https://doi.org/10.1016/j.ins.2019.08.072
Hameed, Z., et al. (2020). Breast cancer histopathology image classification using an ensemble of deep learning models. Sensors, 20, 4373–4389. https://doi.org/10.3390/s20164373
Lin, C. J., & Jeng, S. Y. (2020). Optimization of deep learning network parameters using uniform experimental design for breast cancer histopathological image classification. Diagnostics, 10, 662–672. https://doi.org/10.3390/diagnostics10090662
Barzekar, H., & Yu, Z. (2022). C-Net: A reliable convolutional neural network for biomedical image classification. Expert Systems with Applications, 187, 1–9. https://doi.org/10.1016/j.eswa.2021.116003
Majumdar, S., Pramanik, P., & Sarkar, R. (2023). Gamma function based ensemble of CNN models for breast cancer detection in histopathology images. Expert Systems with Applications, 213, 1–14. https://doi.org/10.1016/j.eswa.2022.119022
Chakraborty, J., et al. (2015). Detection of the nipple in mammograms with Gabor filters and the Radon transform. Biomedical Signal Processing and Control, 15, 80–89. https://doi.org/10.1016/j.bspc.2014.09.001
Liu, Y., et al. (2020). Breast tumors recognition based on edge feature extraction using support vector machine. Biomedical Signal Processing and Control, 58, 101825–101832. https://doi.org/10.1016/j.bspc.2019.101825
Rezaeilouyeh, H., Mollahosseini, A., & Mahoor, M. H. (2016). Microscopic medical image classification framework via deep learning and shearlet transform. Journal of Medical Imaging, 3(4), 1–23. https://doi.org/10.1117/1.jmi.3.4.044501
Drelie, Gelasca, E., et al. (2008). Evaluation and benchmark for biological image segmentation. In 2008 15th IEEE International Conference on Image Processing (pp. 1816–1819). IEEE.
Budak, Ü., & Güzel, A. B. (2020). Automatic grading system for diagnosis of breast cancer exploiting co-occurrence shearlet transform and histogram features. IRBM, 41(2), 106–114. https://doi.org/10.1016/j.irbm.2020.02.001
Candès, E. J., & Donoho, D. L. (2004). New tight frames of curvelets and optimal representations of objects with piecewise C2 singularities. Communications on Pure and Applied Mathematics, 57(2), 219–266. https://doi.org/10.1002/cpa.10116
Guo, K., Kutyniok, G., & Labate, D. (2005). Sparse multidimensional representations using anisotropic dilation and shear operators. In International Conference on the Interaction between Wavelets and Splines (pp. 189–201).
Grohs, P., et al. (2014). Parabolic molecules: Curvelets, shearlets, and beyond. In G. E. Fasshauer & L. L. Schumaker (Eds.), Springer Proceedings in Mathematics and Statistics (pp. 141–172). Springer International Publishing.
Easley, G., Labate, D., & Lim, W. Q. (2008). Sparse directional image representations using the discrete shearlet transform. Applied and Computational Harmonic Analysis, 25(1), 25–46. https://doi.org/10.1016/j.acha.2007.09.003
Alinsaif, S., & Lang, J. (2019). Shearlet-based techniques for histological image classification. In IEEE International Conference on Bioinformatics and Biomedicine (BIBM) (pp. 1424–1431). IEEE.
Spanhol, F. A., et al. (2016). A dataset for breast cancer histopathological image classification. IEEE Transactions on Biomedical Engineering, 63(7), 1455–1462. https://doi.org/10.1109/TBME.2015.2496264
Khairi, S. S. M., et al. (2023). Comparative analysis of image denoising techniques for histopathology images. In The 7th International Conference on Quantitative Sciences and its Applications (ICOQSIA2022) (pp. 040007-1–040007-6). AIP Publishing.
Sajid, U., et al. (2023). Breast cancer classification using deep learned features boosted with handcrafted features. Biomedical Signal Processing and Control, 86(C), 105353–105364. https://doi.org/10.1016/j.bspc.2023.105353
Sharma, H., et al. (2017). Deep convolutional neural networks for automatic classification of gastric carcinoma using whole slide images in digital histopathology. Computerized Medical Imaging and Graphics, 61, 2–13. https://doi.org/10.1016/j.compmedimag.2017.06.001
Loock, S. (2011). pyShearLab - A Python 2D Shearlet Toolbox. https://github.com/stefanloock/pyshearlab
Hoens, T. R., & Chawla, N. V. (2013). Imbalanced datasets: From sampling to classifiers. In Imbalanced Learning (pp. 43–59). John Wiley & Sons, Inc.
Krizhevsky, A., Sutskever, I., & Hinton, G. E. (2012). ImageNet classification with deep convolutional neural networks. In Advances in Neural Information Processing Systems (pp. 1097–1105).
Janowczyk, A., & Madabhushi, A. (2016). Deep learning for digital pathology image analysis: A comprehensive tutorial with selected use cases. Journal of Pathology Informatics, 7(1), 29. https://doi.org/10.4103/2153-3539.186902
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Siti Shaliza Mohd Khairi, Mohd Aftar Abu Bakar, Mohd Almie Alias, Sakhinah Abu Bakar, Nurwahyuna Rosli, Mohsen Farid

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.














