Phenolic constituents from the tree barks of garcinia cf cymosa and their antioxidant and antibacterial activities


  • Yuliar Yuliar
  • Yunazar Manjang
  • Sanusi Ibrahim
  • Sjamsul Arifin Achmad



Antibacterial, antioxidant, flavanol, Garcinia cf cymosa, xanthones,


Two isoprenylated xanthones, α-mangostin (1) and β-mangostin (2) were isolated from the tree barks of Garcinia cf cymosa, along with the flavanol epicatechin (3). Their structures were elucidated by analysis of spectroscopic data. Compounds 1-3 exhibited moderate in vitro antibacterial activity against Staphylococcus aureus and Bacillus sp, while in the 1,2-diphenyl-picryl-hydrazyl (DPPH) antioxidant assay system only compound 3 showed moderate free radical scavenging activity, with IC50 value of 41.8 ppm.


A. Cronquist, An Integrated System of Classification of Flowering Plants, Columbia University Press, New York, 1981, 337-340.

L. M. Perry, Medicinal Plants of East and Southeast Asia, The MIT Press, Massachusetts, 1980, 174-175

S. A. Achmad, E. H. Hakim, L. Makmur, Y. M. Syah, D. Juliawaty, Mujahidin, Chemistry and Uses of Indonesian Medinal Plants, ITB Publisher, 2010, 147-164.

S. Suksamrarn, N. Suwannapoch, P. Ratananukul, N. Aroonlerk, A. Suksamrarn, J. Nat. Prod., 65 (2002) 761-763.

S. Suksamrarn, N. Suwannapoch, W. Phakhodee, J. Thanuhiranlert, P. Ratananukul, N. Chimnoi, A. Suksamrarn, Chem. Pherm. Bull, 51 (2003) 857-859.

S. Suksamram, O. Komutiban, P. Ratananukul, N. Chimnoi, N. Nartpommatulee, A. Suksamram, Chem. Pherm. Bull, 54 (20060 301-305.

S. X. Chen, M. Wan, B. N. Loh, Planta Med, 62 (1996) 381-382.

P. Yates, G. H. Stout, J. Amer. Chem. Soc., 80 (1958) 1691-1700.

A. Jefferson, A. J. Quillinan, F. Scheinmann, K. Y. Sim, Aust. J. Chem., 23 (1970) 2539-2543.

P. Yates, H. B. Bhat, Structure of β-mangostin, Canadian J, Chem., 46 (1968) 3770-3772.

T. R. Govindachari, P. S. Kalyanaraman, N. Muthukumaraswamy, B. R. Pai, Tetrahedron, 27 (1971) 3919-3926.

Lukis, Indo. J. Chem., 9 (2009) 321-327.