Effect of organic and aqueous dispersion medium on the development of polystyrene nanoparticles in nanoprecipitation method


  • Attaullah Bukhari
  • Ani Idris
  • Madiha Atta




Nanoprecipitation, Dispersion phase, Polystyrene, Nanoparticles


The purpose of this study is to develop polystyrene nanoparticles using nanoprecipitation method. Formation of nanoparticles from pre-polymer by nanoprecipitation is a beneficial technique involving the diffusion of polymer phase into dispersion phase. However, selection of solvent /non-solvent couple has intensive influence on nanoprecipitation of specific polymer. In this study the potential of chloroform (CHCl3) and tetrahydrofuran (THF) is explored as the solvent for polystyrene. Effect of dispersion phase; methanol, chloroform, acetone and water have been investigated on nanoprecipitation of polystyrene. It was found that the addition of surfactants enhanced the stability of nanoparticles.Tween-40 has a more pronounced stabilizing effect than Pluronic F-68 on polystyrene nanoparticles in aqueous phase. More stable nanoparticles of polystyrene were obtained in the aqueous medium containing 2-g/L of Tween-40. Interface interaction of mixing phases and surface active agents affect the size and stability of nanoparticles in nanoprecipitation.


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