Effects of surfactants on antibacterial drugs – A brief review


  • Mohd Amir Asyraf Mohd Hamzah Universiti Teknologi Malaysia
  • Claira Arul Aruldass Universiti Teknologi Malaysia
  • Siti Aminah Setu Universiti Teknologi Malaysia




Surfactants, antibacterial activity, critical micelle concentration (CMC)


More than half of the reported new discovered/invented drugs are ones with poor solubility, absorption or both. These are the crucial issues that can affect the bioavailability of the drugs. Therefore, improving solubility of poor-soluble drugs is absolutely important. One of the methods to solubilize them in biological fluids is using surfactants. Surfactants are an amphiphilic organic compound containing hydrophilic and lipophilic parts that allow it to reduce the surface tension between two opposite polar phases.  Several popular methods used to determine critical micelle concentration which includes surface tension, conductivity and UV-vis spectroscopy. These surfactants plays number of roles in antibacterial compound synthesis include size reduction agent, stabilizer, solubilizer and drug-carrier. This review will also critically discuss on the roles of surfactants in antibacterial compound synthesis/production and its effect on the antibacterial activity of the drugs.  

Author Biographies

Mohd Amir Asyraf Mohd Hamzah, Universiti Teknologi Malaysia

MSc Student

Department of Chemistry

Faculty of Science

Claira Arul Aruldass, Universiti Teknologi Malaysia


Department of Chemistry

Faculty of Science



Department of Chemistry

Faculty of Science

Siti Aminah Setu, Universiti Teknologi Malaysia

Senior Lecturer

Department of Chemistry

Faculty of Science


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