Precision in Uric Acid Detection: Unlocking Higher Sensitivity with Zinc Oxide-Coated Tapered No-Core Fibre-Based Sensor

Muhammad Ilham Ahmad Zaini; Mohamad Farid Izuan Azmi; Ahmad Fakhrurrazi Ahmad Noorden; Suzairi Daud

doi:10.11113/mjfas.v21n1.4009

Authors

Muhammad Ilham Ahmad Zaini Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, Malaysia
Mohamad Farid Izuan Azmi Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, Malaysia
Ahmad Fakhrurrazi Ahmad Noorden Department of Physics, Kulliyah of Science, International Islamic University Malaysia, Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia
Suzairi Daud ᵃDepartment of Physics, Faculty of Science, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, Malaysia ᵇLaser Center, Ibnu Sina Institute for Scientific & Industrial Research, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia

DOI:

https://doi.org/10.11113/mjfas.v21n1.4009

Keywords:

Uric acid sensor, Tapered NCF, Zinc Oxide.

Abstract

In this paper, ZnO coated non tapered and tapered no-core fibre (NCF) were developed and experimentally demonstrated for the detection of changes in the uric acid (UA) concentrations. The fabricated main optical fibre-based sensor used non tapered and tapered NCF sandwiched in between SMF region. The tapered NCF by CO₂ laser technique to achieve a waist diameter of 19.17 µm. The non tapered NCF was tested under the UA solutions for comparison purposes. The non tapered and tapered NCF sensing regions were then coated with ZnO solution using the dip-coating method. The ZnO was chosen as the coating due to its remarkable properties such as high transmittance, and good electrical conductivity. It is also known as effective in immobilizing with low isoelectric point (IEP) acidic proteins. Non-tapered UV-Vis spectroscopy was used to characterize the element of the thin composite film. The sensing performance test was performed by using different concentrations of UA solutions ranging from 100 µM to 800 µM for both non tapered and tapered NCF sensors. From the results, the tapered NCF biosensor with a coating of ZnO shows an excellent sensitivity than the non tapered NCF biosensor with the highest sensitivity of 0.00775 ± 0.00072 nm/µM. The reversibility, reproducibility, and reusability test of the designated optical fibre biosensor were also analysed and discussed in this paper.

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