Predictive Value of Multi-Phase CT Radiomics in Delineating Early and Advanced T Staging of Colon Cancer

Authors

  • Kun Ma Department of Biomedical Engineering & Health Sciences, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
  • Haobo Shi Department of Radiology, Zhujiang Hospital, Southern Medical University, Haizhu District, Guangzhou, Guangdong, China
  • Tian Swee Tan ᵃDepartment of Biomedical Engineering & Health Sciences, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia ᵇIJN-UTM Cardiovascular Engineering Centre, Institute of Human Centered Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
  • Muhammad Amir As'ari ᵃDepartment of Biomedical Engineering & Health Sciences, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia ᶜSport Innovation & Technology Centre, Institute of Human Centered Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
  • Yan Chai Hum Department of Mechatronics and Biomedical Engineering, Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Malaysia
  • Jahanzeb Sheikh ᵃDepartment of Biomedical Engineering & Health Sciences, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia ᶠDepartment of Biomedical Engineering, Sir Syed University of Engineering &Technology, Karachi, Pakistan
  • Wei Huang Department of Radiology, Zhujiang Hospital, Southern Medical University, Haizhu District, Guangzhou, Guangdong, China
  • Kah Meng Leong ᵃDepartment of Biomedical Engineering & Health Sciences, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia ʰDepartment of Electrical & Electronics Engineering, Faculty Of Engineering & Information Technology, Southern University College, Malaysia
  • Matthias Foh Thye Tiong Department of Biomedical Engineering & Health Sciences, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
  • Madeeha Sadia Department of Biomedical Engineering, NED University of Engineering and Technology, Pakistan
  • Zhibo Wen Department of Radiology, Zhujiang Hospital, Southern Medical University, Haizhu District, Guangzhou, Guangdong, China

DOI:

https://doi.org/10.11113/mjfas.v20n5.3667

Keywords:

T staging, colon cancer, multiple-phase CT, radiomics.

Abstract

This study leveraged the power of multi-phase CT radiomics, which extracts detailed features from multi-phase images, to explore the distinction between early (T1-T2) and advanced (T3-T4) colon cancer stages in each of multiple phases, providing valuable insights to healthcare professionals and enhancing their decision-making capabilities. A total of 191 patients with surgically confirmed primary colon cancer were retrospectively included, and multi-phase CT scans (non-enhanced contrast phase, arterial phase, portal venous phase, and delayed phase) were conducted within one week before surgery. Three-dimensional segmentation of colonic tumors was performed on the images of the four phases, and radiomics features of each colonic tumor were automatically extracted. Minimum redundancy maximum relevance (mRMR) was applied to features selection in each of the four phases. The least absolute shrinkage and selection operator logistic regression was conducted to determine the association between radiomics features and early (T1-T2) and advanced (T3-T4) stages of colon cancer. Additionally, diagnostic performance comparison was carried out in four phases. The mean (±SD) age of the 191 individuals was 61.87±13.137 years, with females comprising 43.5% of the cohort. The selected features for the non-enhanced, arterial, portal venous, and delayed phases numbered 7, 11, 6, and 10, respectively. In the test set, the AUC values for the on-enhanced, arterial, portal venous, and delayed phases were 0.86 (0.76-0.96), 0.84 (0.73-0.94), 0.82 (0.71-0.93), and 0.86 (0.75-0.97), with corresponding accuracies of 0.84, 0.80, 0.75, and 0.88, sensitivities of 0.73, 0.64, 0.86, and 0.68, and specificities of 0.91, 0.91, 0.68, and 1.00, respectively. DeLong's test revealed no statistically significant differences in the AUC values between the four phases within the test sets (P = 0.3233~ 0.9912). Multi-phase CT radiomics demonstrated substantial value in differentiating between early (T1-T2) and advanced (T3-T4) stages of patients with colon cancer.

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Published

15-10-2024

Issue

Vol. 20 No. 5 (2024): September - October

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Article

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Copyright (c) 2024 Kun Ma, Haobo Shi, Tian Swee Tan, Muhammad Amir As'ari, Yan Chai Hum, Jahanzeb Sheikh, Wei Huang, Kah Meng Leong, Matthias Foh Thye Tiong, Madeeha Sadia, Zhibo Wen

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