Optimum conditions for the synthesis of high solubility carboxymethyl chitosan
Keywords:synthesis, solubility, carboxymethyl chitosan
A research on optimizing the synthesis conditions to obtain carboxymethyl chitosan with the highest solubility in 1%(v/v) acetic acid solvent have been performed. Optimization was performed by varying: the concentration of NaOH during alkalizing the chitosan, chitosan: monochloroacetic acid ratio, temperature and reaction time. This study uses a full factorial experimental design. The results showed that the highest solubility was found in 40% (w/v) NaOH concentration, chitosan to monochloroacetic acid ratio of 1:7, reaction temperature of 80°C and reaction time at 4 hours with the solubility up to 63.78 mg /mL. IR and 1H-NMR spectra showed that the synthesis gave result to carboxymethyl chitosan. Results of physical characterization of carboxymethyl chitosan at the highest solubility showed the value of water content, ash content, molecular weight, and swelling effects up to 14.27%, 8.48%, 2,86978 x 105 g/mol; and 884.19%, respectively.
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