A Review on Molecularly Imprinted Polymer (MIP) for Electrochemical Sensor Development
DOI:
https://doi.org/10.11113/mjfas.v18n3.2252Keywords:
Molecularly Imprinted Polymer, Electrochemical Sensor, Polymerization,Abstract
Molecularly imprinted polymers (MIPs) technology has been studied extensively for multiple applications including analyte detection and chemical separation in the field of medical, pharmaceutical, food safety, and environment. Electrochemical sensors were benefitted from MIPs technology due to their chemical and physical robustness, high sensitivity, selectivity and stability, simple fabrication process, and low-cost of production. The incorporation of MIPs has allowed the development of sensors without biological elements. However, the optimization of the imprinted products requires optimal synergistic effect of multiple factors including materials selection and synthesis techniques. This optimization will form specific recognition cavities for template molecules in the polymeric matrix. This manuscript presents a summary of various MIPs synthesis techniques and performance analysis based on recent studies. The challenges faced in MIPs technology were also discussed to help future researchers in improving technology and boosting commercialization potential against the conventional electrochemical sensor.
References
Abbasy, L. et al. (2020) ‘Development of a reliable bioanalytical method based on prostate specific antigen trapping on the cavity of molecular imprinted polymer towards sensing of PSA using binding affinity of PSA-MIP receptor: A novel biosensor’, Journal of Pharmaceutical and Biomedical Analysis, 188, p. 113447. doi: 10.1016/j.jpba.2020.113447.
Adumitrăchioaie, A. et al. (2018) ‘Electrochemical methods based on molecularly imprinted polymers for drug detection. A review’, International Journal of Electrochemical Science, pp. 2556–2576. doi: 10.20964/2018.03.75.
Ahmad, A. L., Lah, N. F. C. and Low, S. C. (2018) ‘Configuration of molecular imprinted polymer for electrochemical atrazine detection’, Journal of Polymer Research, 25(11), pp. 1–9. doi: 10.1007/s10965-018-1595-2.
Alenazi, N. A., Manthorpe, J. M. and Lai, E. P. C. (2016) ‘Selectivity enhancement in molecularly imprinted polymers for binding of bisphenol A’, Sensors (Switzerland), 16(10), pp. 1–12. doi: 10.3390/s16101697.
Alizadeh, T. et al. (2017) ‘Development of a highly selective and sensitive electrochemical sensor for Bi3+ determination based on nano-structured bismuth-imprinted polymer modified carbon/carbon nanotube paste electrode’, Sensors and Actuators, B: Chemical. Elsevier B.V., 245, pp. 605–614. doi: 10.1016/j.snb.2017.02.024.
Alvarez-Lorenzo, C. and Concheiro, A. (2004) ‘Molecularly imprinted polymers for drug delivery’, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, pp. 231–245. doi: 10.1016/j.jchromb.2003.12.032.
Andersson, L. I. (2000) ‘Efficient sample pre-concentration of bupivacaine from human plasma by solid-phase extraction on molecularly imprinted polymers’, Analyst, 125(9), pp. 1515–1517. doi: 10.1039/b005386o.
Arvand, M., Zamani, M. and Sayyar Ardaki, M. (2017) ‘Rapid electrochemical synthesis of molecularly imprinted polymers on functionalized multi-walled carbon nanotubes for selective recognition of sunset yellow in food samples’, Sensors and Actuators, B: Chemical, 243, pp. 927–939. doi: 10.1016/j.snb.2016.12.077.
Bt Ahamad Mashat, Z. et al. (2022) ‘Development of non-enzymatic screen-printed carbon electrode sensor for glucose using cyclic voltammetry’, Environmental and Toxicology Management, 2(1 SE-Articles), pp. 14–20. doi: 10.33086/etm.v2i1.2542.
Bui, B. T. S. and Haupt, K. (2010) ‘Molecularly imprinted polymers: Synthetic receptors in bioanalysis’, Analytical and Bioanalytical Chemistry, pp. 2481–2492. doi: 10.1007/s00216-010-4158-x.
Chen, L. et al. (2016a) ‘Molecular imprinting: Perspectives and applications’, Chemical Society Reviews. doi: 10.1039/c6cs00061d.
Chen, L. et al. (2016b) ‘Molecular imprinting: Perspectives and applications’, Chemical Society Reviews. Royal Society of Chemistry, pp. 2137–2211. doi: 10.1039/c6cs00061d.
Chen, L., Xu, S. and Li, J. (2011) ‘Recent advances in molecular imprinting technology: Current status, challenges and highlighted applications’, Chemical Society Reviews. doi: 10.1039/c0cs00084a.
Cheong, W. J., Yang, S. H. and Ali, F. (2013) ‘Molecular imprinted polymers for separation science: A review of reviews’, Journal of Separation Science, pp. 609–628. doi: 10.1002/jssc.201200784.
Cieplak, M. et al. (2015) ‘Selective electrochemical sensing of human serum albumin by semi-covalent molecular imprinting’, Biosensors and Bioelectronics. Elsevier Ltd, 74, pp. 960–966. doi: 10.1016/j.bios.2015.07.061.
Crapnell, R. D. et al. (2020) ‘Molecularly imprinted polymer based electrochemical biosensors: Overcoming the challenges of detecting vital biomarkers and speeding up diagnosis’, Talanta Open, 2, p. 100018. doi: 10.1016/j.talo.2020.100018.
Cui, B. et al. (2020) ‘Molecularly imprinted polymers for electrochemical detection and analysis: progress and perspectives’, Journal of Materials Research and Technology. Korea Institute of Oriental Medicine, 9(6), pp. 12568–12584. doi: 10.1016/j.jmrt.2020.08.052.
Cui, F., Zhou, Z. and Zhou, H. S. (2020) ‘Molecularly imprinted polymers and surface imprinted polymers based electrochemical biosensor for infectious diseases’, Sensors (Switzerland), 20(4). doi: 10.3390/s20040996.
Denmark, D. J., Mohapatra, S. and Mohapatra, S. S. (2020) ‘Point-of-Care Diagnostics: Molecularly Imprinted Polymers and Nanomaterials for Enhanced Biosensor Selectivity and Transduction’, The EuroBiotech Journal, 4(4), pp. 184–206. doi: 10.2478/ebtj-2020-0023.
Farooq, S. et al. (2022) ‘Application, advancement and green aspects of magnetic molecularly imprinted polymers in pesticide residue detection’, Science of The Total Environment, 804, p. 150293. doi: 10.1016/j.scitotenv.2021.150293.
Fizir, M. et al. (2020) ‘A mini review on molecularly imprinted polymer based halloysite nanotubes composites: innovative materials for analytical and environmental applications’, Reviews in Environmental Science and Biotechnology. Springer Netherlands, 19(2), pp. 241–258. doi: 10.1007/s11157-020-09537-x.
Fresco-Cala, B., Batista, A. D. and Cárdenas, S. (2020) ‘Molecularly imprinted polymer micro- And nano-particles: a review’, Molecules, p. 4740. doi: 10.3390/molecules25204740.
Fu, Y. et al. (2021) ‘Magnetic molecularly imprinting polymers, reduced graphene oxide, and zeolitic imidazolate frameworks modified electrochemical sensor for the selective and sensitive detection of catechin’, Microchimica Acta, 188(3), pp. 1–9. doi: 10.1007/s00604-021-04724-1.
Haupt, K., Dzgoev, A. and Mosbach, K. (1998) ‘Assay system for the herbicide 2,4-dichlorophenoxyacetic acid using a molecularly imprinted polymer as an artificial recognition element’, Analytical Chemistry, 70(3), pp. 628–631. doi: 10.1021/ac9711549.
Healy, D. A. et al. (2007) ‘Biosensor developments: application to prostate-specific antigen detection’, Trends in Biotechnology, pp. 125–131. doi: 10.1016/j.tibtech.2007.01.004.
Hwang, C.-C. and Lee, W.-C. (2002) C hromatographic characteristics of cholesterol-imprinted polymers prepared by covalent and non-covalent imprinting methods, Journal of Chromatography A.
El Jaouhari, A. et al. (2020) ‘Enhanced molecular imprinted electrochemical sensor based on zeolitic imidazolate framework/reduced graphene oxide for highly recognition of rutin’, Analytica Chimica Acta. Elsevier B.V., 1106, pp. 103–114. doi: 10.1016/j.aca.2020.01.039.
Kugimiya, A. and Takei, H. (2008) ‘Selectivity and recovery performance of phosphate-selective molecularly imprinted polymer’, Analytica Chimica Acta, 606(2), pp. 252–256. doi: 10.1016/j.aca.2007.11.025.
Lenain, P. et al. (2015) ‘Affinity sensor based on immobilized molecular imprinted synthetic recognition elements’, Biosensors and Bioelectronics, 69, pp. 34–39. doi: 10.1016/j.bios.2015.02.016.
Li, R. et al. (2019) ‘Advances in molecularly imprinting technology for bioanalytical applications’, Sensors (Switzerland), pp. 1–34. doi: 10.3390/s19010177.
Liang, Y. et al. (2017) ‘High sensitive and selective graphene oxide/molecularly imprinted polymer electrochemical sensor for 2,4-dichlorophenol in water’, Sensors and Actuators, B: Chemical. Elsevier B.V., 240, pp. 1330–1335. doi: 10.1016/j.snb.2016.08.137.
Liu, H. et al. (2021) ‘A review on the use of ionic liquids in preparation of molecularly imprinted polymers for applications in solid-phase extraction’, TrAC - Trends in Analytical Chemistry, p. 116132. doi: 10.1016/j.trac.2020.116132.
Mahony, J. O. et al. (2005) ‘Molecularly imprinted polymers - Potential and challenges in analytical chemistry’, Analytica Chimica Acta, 534(1), pp. 31–39. doi: 10.1016/j.aca.2004.07.043.
Maria C G, A. et al. (2020) ‘Molecularly imprinted PEDOT on carbon fiber paper electrode for the electrochemical determination of 2,4-dichlorophenol’, Synthetic Metals, 261, p. 116309. doi: 10.1016/j.synthmet.2020.116309.
Md Shakhih, M. F. et al. (2021) ‘Review—Enzymatic and Non-Enzymatic Electrochemical Sensor for Lactate Detection in Human Biofluids’, Journal of The Electrochemical Society. doi: 10.1149/1945-7111/ac0360.
Mengarda, P. et al. (2019) ‘Determination of lactate levels in biological fluids using a disposable ion-selective potentiometric sensor based on polypyrrole films’, Sensors and Actuators, B: Chemical. Elsevier, 296(November 2018), p. 126663. doi: 10.1016/j.snb.2019.126663.
Motaharian, A. et al. (2016) ‘Molecularly imprinted polymer nanoparticles-based electrochemical sensor for determination of diazinon pesticide in well water and apple fruit samples’, Analytical and Bioanalytical Chemistry. Springer Verlag, 408(24), pp. 6769–6779. doi: 10.1007/s00216-016-9802-7.
Motaharian, A. et al. (2019) ‘Electrochemical determination of atypical antipsychotic drug quetiapine using nano-molecularly imprinted polymer modified carbon paste electrode’, Analytica Chimica Acta, 1097, pp. 214–221. doi: 10.1016/j.aca.2019.11.020.
Parisi, O. I. et al. (2022) ‘Functional Biomaterials The Evolution of Molecular Recognition: From Antibodies to Molecularly Imprinted Polymers (MIPs) as Artificial Counterpart’. doi: 10.3390/jfb13010012.
Pedroso, M. M. et al. (2017) ‘Electrochemical sensor for dodecyl gallate determination based on electropolymerized molecularly imprinted polymer’, Sensors and Actuators, B: Chemical, 253, pp. 180–186. doi: 10.1016/j.snb.2017.06.127.
Pereira, T. C. and Stradiotto, N. R. (2019) ‘Electrochemical sensing of lactate by using an electrode modified with molecularly imprinted polymers, reduced graphene oxide and gold nanoparticles’, Microchimica Acta. Microchimica Acta, 186(12). doi: 10.1007/s00604-019-3898-3.
Puiu, M., Jaffrezic-Renault, N. and Bala, C. (2017) ‘Biomimetic Sensors Based on Molecularly Imprinted Interfaces’, Comprehensive Analytical Chemistry. Elsevier B.V., 77, pp. 147–177. doi: 10.1016/bs.coac.2017.05.002.
Ramanavičius, S. et al. (2022) ‘Electrochemically Deposited Molecularly Imprinted Polymer-Based Sensors’. doi: 10.3390/s22031282.
Rassaei, L. et al. (2014) ‘Lactate biosensors: Current status and outlook’, Analytical and Bioanalytical Chemistry, 406(1), pp. 123–137. doi: 10.1007/s00216-013-7307-1.
Rebelo, T. S. C. R. et al. (2019) ‘Molecularly imprinted polymer SPE sensor for analysis of CA-125 on serum’, Analytica Chimica Acta, 1082, pp. 126–135. doi: 10.1016/j.aca.2019.07.050.
Refaat, D. et al. (2019) ‘Strategies for molecular imprinting and the evolution of MIP nanoparticles as plastic antibodies—synthesis and applications’, International Journal of Molecular Sciences, p. 6304. doi: 10.3390/ijms20246304.
Sarpong, K. A. et al. (2019) ‘The Development of Molecularly Imprinted Polymers in the Clean-Up of Water Pollutants: A Review’, American Journal of Analytical Chemistry, 10(05), pp. 202–226. doi: 10.4236/ajac.2019.105017.
Sikaris, K. (2011) ‘Prostate specific antigen’, Australian Prescriber, 34(6), pp. 186–188. doi: 10.18773/austprescr.2011.096.
Sun, L. et al. (2018) ‘Synthesis and applications of molecularly imprinted polymers modified TiO2 nanomaterials: A review’, Polymers, p. 1248. doi: 10.3390/polym10111248.
Tio et al. (2018) ‘Synthesis and Applications of Molecularly Imprinted’, 10, p. 1248. doi: 10.3390/polym10111248.
Vasapollo, G. et al. (2011) ‘Molecularly imprinted polymers: Present and future prospective’, International Journal of Molecular Sciences, pp. 5908–5945. doi: 10.3390/ijms12095908.
Wackerlig, J. and Schirhagl, R. (2016) ‘Applications of Molecularly Imprinted Polymer Nanoparticles and Their Advances toward Industrial Use: A Review’, Analytical Chemistry, pp. 250–261. doi: 10.1021/acs.analchem.5b03804.
Yang, C. et al. (2019) ‘Molecularly imprinted polymer based sensor directly responsive to attomole bovine serum albumin’, Talanta, 196, pp. 402–407. doi: 10.1016/j.talanta.2018.12.097.
Yücebaş, B. B. et al. (2020) ‘Molecular imprinted polymer based electrochemical sensor for selective detection of paraben’, Sensors and Actuators, B: Chemical. Elsevier B.V., 305, p. 127368. doi: 10.1016/j.snb.2019.127368.
Yue, X. et al. (2019) ‘Selective electrochemical determination of tertiary butylhydroquinone in edible oils based on an in-situ assembly molecularly imprinted polymer sensor’, Food Chemistry, 289, pp. 84–94. doi: 10.1016/j.foodchem.2019.03.044.
Zaidi, S. A. (2016) ‘Latest trends in molecular imprinted polymer based drug delivery systems’, RSC Advances, pp. 88807–88819. doi: 10.1039/c6ra18911c.
Downloads
Published
Issue
Section
License
Copyright (c) 2022 Anis Suzziani Rosslan, Muhammad Faiz Md Shakhih, Farah Nabila Mustafa Amirrudin, Asnida Abdul Wahab, Faizuan Abdullah, Muhammad Hanif Ramlee
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.