Medium-chain fatty acids in nutritional therapy: A review


  • Izzati Nur Zulkanain Institute of Medical and Molecular Biotechnology, Universiti Teknologi MARA, Cawangan Selangor, 47000 Sg. Buloh, Malaysia
  • Sharaniza Ab-Rahim Dept. of Biochemistry and Molecular Medicine, Faculty of Medicine, Universiti Teknologi MARA, Cawangan Selangor, 47000 Sg. Buloh, Malaysia
  • Siti Nazrina Camalxaman Centre of Medical Laboratory Technology, Faculty of Health Sciences, Universiti Teknologi MARA, Cawangan Selangor, 42300 Bandar Puncak Alam, Kuala Selangor, Malaysia
  • Musalmah Mazlan Dept. of Biochemistry and Molecular Medicine, Faculty of Medicine, Universiti Teknologi MARA, Cawangan Selangor, 47000 Sg. Buloh, Malaysia



medium chain fatty acid (MCFA), medium chain triglycerides (MCT), nutritional therapy, diabetes mellitus type 2, cardiovascular disease


Medium-Chain Fatty Acids (MCFA) are saturated fats with aliphatic rings of 6-12 carbons. It is widely accepted that the metabolism of MCFA induces ketogenesis in the liver. Ketone bodies have been suggested to produce larger amounts of energy compared to glucose. Its benefit in providing an alternative source of energy has been as one of the strategies to prevent disease development especially those diseases that are associated with glucose metabolism or mitochondrial dysfunction. The current review highlights the nutritional impacts of MCFA and its utilization in disease therapy.

Author Biographies

Izzati Nur Zulkanain, Institute of Medical and Molecular Biotechnology, Universiti Teknologi MARA, Cawangan Selangor, 47000 Sg. Buloh, Malaysia

Institute of Medical and Molecular Biotechnology

Sharaniza Ab-Rahim, Dept. of Biochemistry and Molecular Medicine, Faculty of Medicine, Universiti Teknologi MARA, Cawangan Selangor, 47000 Sg. Buloh, Malaysia

Dept. of Biochemistry and Molecular Medicine, Senior Lecturer

Siti Nazrina Camalxaman, Centre of Medical Laboratory Technology, Faculty of Health Sciences, Universiti Teknologi MARA, Cawangan Selangor, 42300 Bandar Puncak Alam, Kuala Selangor, Malaysia

Centre of Medical Laboratory Technology, Lecturer

Musalmah Mazlan, Dept. of Biochemistry and Molecular Medicine, Faculty of Medicine, Universiti Teknologi MARA, Cawangan Selangor, 47000 Sg. Buloh, Malaysia

Dept. of Biochemistry and Molecular Medicine, Professor


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