Development of oil-in-water microemulsion encapsulating Vitamin E for thermal and hydrolysis degradation study


  • Khairun Nisa Abdul Rahman University of Malaya
  • Khalisanni Khalid Malaysian Agriculture Research and Development Institute (MARDI)
  • Nurhazirah Mohd Ihsan Universiti Kuala Lumpur- Branch Campus Malaysia Institute of Chemical and Bio-Engineering Technology (UniKL-MICET)
  • Zainurin Md Dom
  • Misni Misran University of Malaya



Vitamin E, tocopherol, tocotrienol, degradation study, microemulsion,


Vitamin E is widely used for medicinal and cosmeceuticals purposes. However, it is easy to degrade by the environment. In this study, the degradation of Gold Tri.E™ was studied and determined. Gold Tri.E™ is a mixture of Vitamin E homologs (tocotrienol and tocopherol) extracted from palm oil (Elais Guineensis). A nanocarrier system has been optimized to encapsulate Gold Tri.E™ from degrading and increasing its stability as a bioactive compound. An oil-in-water (o/w) microemulsion was formulated and optimized as the best carrier to encapsulate Gold Tri.E™ with the mean particle size of 32.60±3.60 nm and 99.99±0.01% encapsulation efficiency (EE). Degradation of the Gold Tri.E™ in o/w microemulsion was significantly reduced as compared to the bare Gold Tri.ETM. This suggested that the system could protect Gold Tri.E™ from thermal and hydrolysis degradation. Thus, the ease of preparation, low-cost production, and small particle size obtained when Gold Tri.E™ encapsulated in this system give promising drug delivery system to encapsulate, protect, and increase the shelf life of Gold Tri.E™.

Author Biographies

Khairun Nisa Abdul Rahman, University of Malaya

Department of Chemistry



Khalisanni Khalid, Malaysian Agriculture Research and Development Institute (MARDI)

Agri-Nanotechnology Program, Biotechnology, and Nanotechnology Research Centre,

Nurhazirah Mohd Ihsan, Universiti Kuala Lumpur- Branch Campus Malaysia Institute of Chemical and Bio-Engineering Technology (UniKL-MICET)

Process Engineering Technology Section

Misni Misran, University of Malaya

Department of Chemistry, Faculty of Science,


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