Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening


  • Shahrul Nizam Ahmad Universiti Teknologi MARA
  • Hadariah Bahron Universiti Teknologi MARA
  • Amalina Mohd Tajuddin Universiti Teknologi MARA
  • Kalavathy Ramasamy Universiti Teknologi MARA




Schiff bases, nickel(II), anticancer, HCT116


Two tetradentate phenolic Schiff base ligands namely 2,2'-((1E,1'E)-(1,2-phenylenebis(azanyl-ylidene))bis(methanylylidene))diphenol, L1H, 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis-(methanylylidene))bis(4-fluorophenol), L1F and their new nickel(II) complexes were successfully synthesized, characterized and evaluated for their in vitro anticancer activities against human colon cancer cell lines, HCT116. The compounds were characterized using FT-IR, 1H and 13C NMR, UV-Visible, elemental analysis and melting point. The anticancer results revealed that the parent ligands were more active than their corresponding complexes with L1F being the most potent anticancer compound with IC50 of 2.8 mg/ml.

Author Biographies

Shahrul Nizam Ahmad, Universiti Teknologi MARA

Department of Chemistry, Faculty of Applied Sciences, Universiti Teknologi MARA

Hadariah Bahron, Universiti Teknologi MARA

Department of Chemistry, Faculty of Applied Sciences, 

Amalina Mohd Tajuddin, Universiti Teknologi MARA

Atta-ur-Rahman Institute for Natural Product Discovey, Level 9, Building FF3, UiTM Selangor, Kampus Puncak Alam


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