Formulation and characterization of self-nano emulsifying drug delivery systems of lemongrass (cymbopogon citratus) essential oil


  • Tri Ujilestari Universitas Gadjah Mada
  • Nanung Danar Dono Universitas Gadjah Mada
  • Bambang Ariyadi Universitas Gadjah Mada
  • Ronny Martien Universitas Gadjah Mada
  • Zuprizal Zuprizal Universitas Gadjah Mada



Cymbopogon citratus, Essential Oil, Nanoemulsion


The present research was aimed to characterize the formula of self-nano emulsifying drug delivery systems (SNEDDS) for lemongrass essential oil. The observation variables included: particle size, zeta potential, and morphology. Meanwhile, the materials consisted of the mixtures of oils (lemongrass essential oil and carrier oil), surfactants, and cosurfactants. Carrier oils were screened as candidates for SNEDDS, and the formula was evaluated for transmittance and emulsification time. The value of the formulation component was lemongrass essential oils, carrier oil (Virgin Coconut Oil), surfactant (Tween 80), and co-surfactant (PEG 400) = 8.34, 8.34, 71.43, and 16.67 % respectively. The formulation had a mean of the nanoemulsion droplet diameters of 20.7 nm with the polydispersity index (PI) 0.378 and potential zeta -73 mV. The transmission electron microscopy demonstrated spherical droplet morphology. This research produced SNEDDS of lemongrass essential oil with nanoparticle size that can be used as feed additive for poultry

Author Biographies

Tri Ujilestari, Universitas Gadjah Mada

Department of Animal Nutrition and Feed Science, Faculty of Animal Science

Nanung Danar Dono, Universitas Gadjah Mada

Department of Animal Nutrition and Feed Science, Faculty of Animal Science

Bambang Ariyadi, Universitas Gadjah Mada

Department of Animal Nutrition and Feed Science, Faculty of Animal Science

Ronny Martien, Universitas Gadjah Mada

Department of Pharmaceutics, Faculty of Pharmacy

Zuprizal Zuprizal, Universitas Gadjah Mada

Department of Animal Nutrition and Feed Science, Faculty of Animal Science


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