Formulation and characterization of self-nano emulsifying drug delivery systems of lemongrass (cymbopogon citratus) essential oil

Authors

  • Tri Ujilestari Universitas Gadjah Mada
  • Nanung Danar Dono Universitas Gadjah Mada
  • Bambang Ariyadi Universitas Gadjah Mada
  • Ronny Martien Universitas Gadjah Mada
  • Zuprizal Zuprizal Universitas Gadjah Mada

DOI:

https://doi.org/10.11113/mjfas.v14n3.1070

Keywords:

Cymbopogon citratus, Essential Oil, Nanoemulsion

Abstract

The present research was aimed to characterize the formula of self-nano emulsifying drug delivery systems (SNEDDS) for lemongrass essential oil. The observation variables included: particle size, zeta potential, and morphology. Meanwhile, the materials consisted of the mixtures of oils (lemongrass essential oil and carrier oil), surfactants, and cosurfactants. Carrier oils were screened as candidates for SNEDDS, and the formula was evaluated for transmittance and emulsification time. The value of the formulation component was lemongrass essential oils, carrier oil (Virgin Coconut Oil), surfactant (Tween 80), and co-surfactant (PEG 400) = 8.34, 8.34, 71.43, and 16.67 % respectively. The formulation had a mean of the nanoemulsion droplet diameters of 20.7 nm with the polydispersity index (PI) 0.378 and potential zeta -73 mV. The transmission electron microscopy demonstrated spherical droplet morphology. This research produced SNEDDS of lemongrass essential oil with nanoparticle size that can be used as feed additive for poultry

Author Biographies

Tri Ujilestari, Universitas Gadjah Mada

Department of Animal Nutrition and Feed Science, Faculty of Animal Science

Nanung Danar Dono, Universitas Gadjah Mada

Department of Animal Nutrition and Feed Science, Faculty of Animal Science

Bambang Ariyadi, Universitas Gadjah Mada

Department of Animal Nutrition and Feed Science, Faculty of Animal Science

Ronny Martien, Universitas Gadjah Mada

Department of Pharmaceutics, Faculty of Pharmacy

Zuprizal Zuprizal, Universitas Gadjah Mada

Department of Animal Nutrition and Feed Science, Faculty of Animal Science

References

Balakumar, K., Raghavan, C. V., Abdu, S. 2013. Self nanoemulsifying drug delivery system (snedds) of rosuvastatin calcium: Design, formulation, bioavailability and pharmacokinetic evaluation. Colloids and Surfaces B: Biointerfaces, 112, 337-343.

Bali, V., Ali, M., Ali, J. 2011. Nanocarrier for the enhanced bioavailability of a cardiovascular agent: In vitro, pharmacodynamic, pharmacokinetic and stability assessment. International Journal of Pharmaceutics, 403(1), 46-56.

Bandyopadhyay, S., Katare, O., Singh, B. 2012. Optimized self nano-emulsifying systems of ezetimibe with enhanced bioavailability potential using long chain and medium chain triglycerides. Colloids and Surfaces B: Biointerfaces, 100, 50-61.

Basalious, E. B., Shawky, N., Badr-Eldin, S. M. 2010. Snedds containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I: Development and optimization. International Journal of Pharmaceutics, 391(1), 203-211.

Chavda, H., Patel, J., Chavada, G., Dave, S., Patel, A., Patel, C. 2013. Self-nanoemulsifying powder of isotretinoin: Preparation and characterization. Journal of Powder Technology, 2013, 1-9.

Eid, A. M. M., Elmarzugi, N., El-Enshasy, H., Arafat, O. M. 2013. A novel swietenia macrophylla oil self-nanoemulsifying system: Development and evaluation. International Journal of Pharmacy and Pharmaceutical Sciences, 5(3) 639-644.

Elnaggar, Y. S., El-Massik, M. A., Abdallah, O. Y. 2009. Self-nanoemulsifying drug delivery systems of tamoxifen citrate: Design and optimization. International Journal of Pharmaceutics, 380(1) 133-141.

Freitas, C., Müller, R. H. 1998. Effect of light and temperature on zeta potential and physical stability in solid lipid nanoparticle (sln™) dispersions. International Journal of Pharmaceutics, 168(2), 221-229.

Gopi, M., Karthik, K., Manjunathachar, H. V., Tamilmahan, P., Kesavan, M., Dashprakash, M., et al. 2014. Essential oils as a feed additive in poultry nutrition. Advances in Animal Veterinary Sciences, 2(1), 1-7.

Jeong, M.-R., Park, P. B., Kim, D.-H., Jang, Y.-S., Jeong, H. S., Choi, S.-H. 2009. Essential oil prepared from cymbopogon citrates exerted an antimicrobial activity against plant pathogenic and medical microorganisms. Mycobiology, 37(1), 48-52.

Jyothi, B. J., Sreelakshmi, K. 2011. Design and evaluation of self-nanoemulsifying drug delivery system of flutamide. Journal of Young Pharmacists, 3(1), 4-8.

Kaur, G., Chandel, P., Harikumar, S. 2013. Formulation development of self nanoemulsifying drug delivery system (snedds) of celecoxib for improvement of oral bioavailability. Pharmacophore, 4(4), 120-133.

Kumar, M., Kumar, V., Roy, D., Kushwaha, R., Vaiswani, S. 2014. Application of herbal feed additives in animal nutrition-a review. International Journal of Livestock Research, 4, 1-8.

Mukhtar, A., Mohamed, K., Amal, O., Ahlam, A. 2012. Effect of different levels of lemon grass oil (lgo) as anatural growth promoter on the performance, carcass yields and serum chemistry of broiler chicks. Egyptian Poultry Science, 33, 1-7.

Müller, R., Jacobs, C., Kayser, O. 2001. Nanosuspensions as particulate drug formulations in therapy: Rationale for development and what we can expect for the future. Advanced Drug Delivery Reviews, 47(1), 3-19.

Nasr, A., Gardouh, A., Ghorab, M. 2016. Novel solid self-nanoemulsifying drug delivery system (s-snedds) for oral delivery of olmesartan medoxomil: Design, formulation, pharmacokinetic and bioavailability evaluation. Pharmaceutics, 8(20), 2-29.

Negrelle, R., Gomes, E. 2007. Cymbopogon citratus (dc.) stapf: Chemical composition and biological activities. Reviesta Brasileira de Plantas Medicinais, 9(1), 80-92.

Onawunmi, G. O. 1989. Evaluation of the antimicrobial activity of citral. Letters in applied microbiology, 9(3), 105-108.

Onawunmi, G. O., Yisak, W.-A., Ogunlana, E. 1984. Antibacterial constituents in the essential oil of cymbopogon citratus (dc.) stapf. Journal of Ethnopharmacology, 12(3), 279-286.

Patel, J., Kevin, G., Patel, A., Raval, M., Sheth, N. 2011. Design and development of a self-nanoemulsifying drug delivery system for telmisartan for oral drug delivery. International Journal of Pharmaceutical Investigation, 1(2), 112-118.

Pouton, C. W. 1997. Formulation of self-emulsifying drug delivery systems. Advanced Drug Delivery Reviews, 25(1), 47-58.

Pratiwi, L., Fudholi, A., Martien, R., Pramono, S. 2016. Design and optimization of self-nanoemulsifying drug delivery systems (snedds) of ethyl acetate fraction from mangosteen peel (garcinia mangostana, l.). International Journal of Pharmatech of Pharmech Research, 9(6), 380-387.

Ranitha, M., Nour, A. H., Sulaiman, Z. A., Nour, A. H. 2014. A comparative study of lemongrass (cymbopogon citratus) essential oil extracted by microwave-assisted hydrodistillation (mahd) and conventional hydrodistillation (hd) method. International Journal of Chemical Engineering and Applications, 5(2), 104-108.

Rowe, R. C., Sheskey, P. J., Weller, P. J. 2006. Handbook of Pharmaceutical Excipients (Vol. 6). London: Pharmaceutical press London.

Saeedi, M., Rafati, M. R., Morteza-Semnani, K., Yazdani Rostam, A., Kelidari, H. R. 2015. Evaluation of effect of tween 80 on characteristics of tadalafil 0.1% suspension. Pharmaceutical and Biomedical Research, 1(2), 35-43.

São Pedro, A., Santo, I., Silva, C., Detoni, C., Albuquerque, E. 2013. The use of nanotechnology as an approach for essential oil-based formulations with antimicrobial activity. Microbial Pathogens and Strategies for Combating Them (Méndez-Vilas, A., ed.) Formatex Research Center Pulisher, 2, 1364-1374.

Savale, S. 2015. A review - self nanoemulsifying drug delivery system (snedds). International Journal of Research in Pharmaceutical and Nano Sciences, 4(6), 385-397.

Sh, A., Abdelrazeik, A., Rakha, O. 2015. Nanoemulsion of jojoba oil, preparation, characterization and insecticidal activity against sitophilus oryzae (coleoptera: Curculionidae) on wheat. International Journal of Agriculture Innovations and Research, 4(1), 72-75.

Shin, S.-W. 2005. Anti-salmonella activity of lemongrass oil alone and in combination with antibiotics. Natural Product Sciences, 11(3), 160-164.

Suganya, T., Senthilkumar, S., Deepa, K., Muralidharan, J., Gomathi, G., Gobiraju, S. 2016. Herbal feed additives in poultry. International Journal of Science, Environment and Technology, 5(3), 1137-1145.

Taha, E. I., Al-Saidan, S., Samy, A. M., Khan, M. A. 2004. Preparation and in vitro characterization of self-nanoemulsified drug delivery system (snedds) of all-trans-retinol acetate. International Journal of Pharmaceutics, 285(1), 109-119.

Wang, L., Dong, J., Chen, J., Eastoe, J., Li, X. 2009. Design and optimization of a new self-nanoemulsifying drug delivery system. Journal of Colloid and Interface Science, 330(2), 443-448.

Wannissorn, B., Jarikasem, S., Siriwangchai, T., Thubthimthed, S. 2005. Antibacterial properties of essential oils from thai medicinal plants. Fitoterapia, 76(2), 233-236.

Zhang, J., Peng, Q., Shi, S., Zhang, Q., Sun, X., Gong, T., et al. 2011. Preparation, characterization, and in vivo evaluation of a self-nanoemulsifying drug delivery system (snedds) loaded with morin-phospholipid complex. International Journal of Nanomedicine, 6, 3405-3414.

Zulfa, Z., Chia, C., Rukayadi, Y. 2016. In vitro antimicrobial activity of cymbopogon citratus (lemongrass) extracts against selected foodborne pathogens. International Food Research Journal, 23(3), 1262-1267.

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Published

03-09-2018