Release of curcumin incorporated in albumin loaded silica

Authors

  • Shafiyah Pondi
  • Leaw Wai Loon
  • Sheela Chandren
  • Hadi Nur Center for Sustainable Nanomaterials (CSNano), Universiti Teknologi Malaysia

DOI:

https://doi.org/10.11113/mjfas.v14n1.1059

Keywords:

Silica, Albumin, Curcumin, Co–carrier, Composition, Release mechanism, Intermolecular interaction,

Abstract

In this work, we have prepared a new drug delivery system consisting of silica (SiO2) as the main carrier, while albumin acted as the co–carrier in order to control the release of drug. The system was prepared by simple wet chemical method. The efficiency of the designed system was tested in the delivery of a hydrophobic drug, curcumin through an in–vitro procedure. The results show that the release percentage of curcumin was increased with the presence of the co–carrier. The intermolecular interaction of curcumin with albumin and the competition between them to locate on the surface of silica affect the release system. Besides, the curcumin release amount was corresponded to the composition of the silica carrier in the systems. Consequently, the potential for silica/albumin use as a drug carrier was ascertained.

Author Biography

Hadi Nur, Center for Sustainable Nanomaterials (CSNano), Universiti Teknologi Malaysia

Hadi Nur was born on the 6th of May 1969. He is specialized in advanced materials and heterogeneous catalysis. His main field in undergraduate and graduate studies was in chemistry and materials engineering at the Institut Teknologi Bandung. He obtained his B.S. and M.Eng. (cum laude) degrees in 1992 and 1995, repectively. Shortly after that, he continued his postgraduate studies in zeolite chemistry at the Universiti Teknologi Malaysia (UTM) as he received his Ph.D. degree in 1998. His postdoctoral studies started with a year as a UTM Postdoctoral Fellow, and with two years as a Japan Society for Promotion of Science (JSPS) Postdoctoral Fellow at Catalysis Research Center (CRC), Hokkaido University, Sapporo, Japan. He continued there as a Center of Excellence (COE) Visiting Researcher at CRC for half a year. In May 2002, he joined the Ibnu Sina Institute for Fundamental Science Studies, Universiti Teknologi Malaysia. He was a visiting scientist at the Institute for Heterogeneous Materials Systems, Helmholtz-Zentrum Berlin for Materials and Energy, Germany from July to September 2015. Currently, he is a full professor at UTM. He has supervised many postgraduate students studying for Ph.D. and M.S. degrees in heterogeneous catalysis and advanced materials, for example, zeolite chemistry and catalysis, photocatalysis, semiconductor nanoparticle-polymer composite, bifunctional oxidative, and acidic catalysts and phase-boundary catalysis. Currently, he and his family enjoy living in Johor Bahru area and are glad that they made the move.

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Published

15-03-2018

Issue

Vol. 14 No. 1 (2018): January - March

Section

Article